γδ T cells are increasingly emerging as crucial immune regulators that can take on innate and adaptive roles in the defence against pathogens. Although they arise within the thymus from the same hematopoietic precursors as conventional αβ T cells, the development of γδ T cells is less well understood. For a special issue of Seminars in Immunology on unconventional T cells we have reviewed the current state of knowledge about the cellular and molecular processes involved in the gener- ation of γδ T cells in human.
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