Publications

108 entries « 1 of 6 »

2023

Liang, Kai Ling; Roels, Juliette; Lavaert, Marieke; Putteman, Tom; Boehme, Lena; Tilleman, Laurentijn; Velghe, Imke; Pegoretti, Valentina; de Walle, Inge Van; Sontag, Stephanie; Vandewalle, Jolien; Vandekerckhove, Bart; Leclercq, Georges; Vlierberghe, Pieter Van; Libert, Claude; Nieuwerburgh, Filip Van; Fischer, Roman; Kontermann, Roland E; Pfizenmaier, Klaus; Doody, Gina; Zenke, Martin; Taghon, Tom

Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF. Journal Article

Nature immunology, 2023, ISSN: 1529-2916.

Abstract | Links | Altmetric

2022

Drobna-Śledzińska, Monika; Maćkowska-Maślak, Natalia; Jaksik, Roman; Kosmalska, Maria; Szarzyńska, Bronisława; Lejman, Monika; Sędek, Łukasz; Szczepański, Tomasz; Taghon, Tom; Vlierberghe, Pieter Van; Witt, Michał; Dawidowska, Małgorzata

Multiomics to investigate the mechanisms contributing to repression of PTPRC and SOCS2 in pediatric T-ALL: Focus on miR-363-3p and promoter methylation. Journal Article

Genes, chromosomes & cancer, 2022, ISSN: 1098-2264.

Abstract | Links | Altmetric

Ingels, Joline; Cock, Laurenz De; Mayer, Rupert L; Devreker, Pam; Weening, Karin; Heyns, Kelly; Lootens, Nele; Smet, Saskia De; Brusseel, Marieke; Munter, Stijn De; Pille, Melissa; Billiet, Lore; Goetgeluk, Glenn; Bonte, Sarah; Jansen, Hanne; Lint, Sandra Van; Leclercq, Georges; Taghon, Tom; Menten, Björn; Vermaelen, Karim; Impens, Francis; Vandekerckhove, Bart

Small-scale manufacturing of neoantigen-encoding messenger RNA for early-phase clinical trials. Journal Article

Cytotherapy, 24 , pp. 213–222, 2022, ISSN: 1477-2566.

Abstract | Links | Altmetric

Wahlen, Sigrid; Matthijssens, Filip; Loocke, Wouter Van; Taveirne, Sylvie; Kiekens, Laura; Persyn, Eva; Ammel, Els Van; Vos, Zenzi De; Munter, Stijn De; Matthys, Patrick; Nieuwerburgh, Filip Van; Taghon, Tom; Vandekerckhove, Bart; Vlierberghe, Pieter Van; Leclercq, Georges

The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency. Journal Article

eLife, 11 , 2022, ISSN: 2050-084X.

Abstract | Links | Altmetric

Kiekens, Laura; Wahlen, Sigrid; Persyn, Eva; Vos, Zenzi De; Taghon, Tom; Vandekerckhove, Bart; Leclercq, Georges

T-BET drives the conversion of human type 3 innate lymphoid cells into functional NK cells. Journal Article

Frontiers in immunology, 13 , pp. 975778, 2022, ISSN: 1664-3224.

Abstract | Links | Altmetric

Roels, Juliette; Hulle, Jolien Van; Lavaert, Marieke; Kuchmiy, Anna; Strubbe, Steven; Putteman, Tom; Vandekerckhove, Bart; Leclercq, Georges; Nieuwerburgh, Filip Van; Boehme, Lena; Taghon, Tom

Transcriptional dynamics and epigenetic regulation of E and ID protein encoding genes during human T cell development. Journal Article

Frontiers in immunology, 13 , pp. 960918, 2022, ISSN: 1664-3224.

Abstract | Links | Altmetric

Persyn, Eva; Wahlen, Sigrid; Kiekens, Laura; Taveirne, Sylvie; Loocke, Wouter Van; Ammel, Els Van; Nieuwerburgh, Filip Van; Taghon, Tom; Vandekerckhove, Bart; Vlierberghe, Pieter Van; Leclercq, Georges

TXNIP Promotes Human NK Cell Development but Is Dispensable for NK Cell Functionality. Journal Article

International journal of molecular sciences, 23 , 2022, ISSN: 1422-0067.

Abstract | Links | Altmetric

Boehme, Lena; Roels, Juliette; Taghon, Tom

Development of γδ T cells in the thymus – A human perspective Journal Article

61-64 , pp. 101662, 2022, ISSN: 1044-5323.

Links | Altmetric

Persyn, Eva; Wahlen, Sigrid; Kiekens, Laura; Loocke, Wouter Van; Siwe, Hannah; Ammel, Els Van; Vos, Zenzi De; Nieuwerburgh, Filip Van; Matthys, Patrick; Taghon, Tom; Vandekerckhove, Bart; Vlierberghe, Pieter Van; Leclercq, Georges

IRF2 is required for development and functional maturation of human NK cells. Journal Article

Frontiers in immunology, 13 , pp. 1038821, 2022, ISSN: 1664-3224.

Abstract | Links | Altmetric

2021

Strubbe, Steven; Taghon, Tom

Modeling of human T cell development in vitro as a read-out for hematopoietic stem cell multipotency. Journal Article

Biochemical Society transactions, 49 , pp. 2113–2122, 2021, ISSN: 1470-8752.

Abstract | Links | Altmetric

Lorenzi, Lucia; Chiu, Hua-Sheng; Cobos, Francisco Avila; Gross, Stephen; Volders, Pieter-Jan; Cannoodt, Robrecht; Nuytens, Justine; Vanderheyden, Katrien; Anckaert, Jasper; Lefever, Steve; Tay, Aidan P; de Bony, Eric J; Trypsteen, Wim; Gysens, Fien; Vromman, Marieke; Goovaerts, Tine; Hansen, Thomas Birkballe; Kuersten, Scott; Nijs, Nele; Taghon, Tom; Vermaelen, Karim; Bracke, Ken R; Saeys, Yvan; Meyer, Tim De; Deshpande, Nandan P; Anande, Govardhan; Chen, Ting-Wen; Wilkins, Marc R; Unnikrishnan, Ashwin; Preter, Katleen De; Kjems, Jørgen; Koster, Jan; Schroth, Gary P; Vandesompele, Jo; Sumazin, Pavel; Mestdagh, Pieter

The RNA Atlas expands the catalog of human non-coding RNAs. Journal Article

Nature biotechnology, 39 , pp. 1453–1465, 2021, ISSN: 1546-1696.

Abstract | Links | Altmetric

Moirangthem, Ranjita Devi; Ma, Kuiying; Lizot, Sabrina; Cordesse, Anne; Olivré, Juliette; de Chappedelaine, Corinne; Joshi, Akshay; Cieslak, Agata; Tchen, John; Cagnard, Nicolas; Asnafi, Vahid; Rausell, Antonio; Simons, Laura; Zuber, Julien; Taghon, Tom; Staal, Frank J T; Pflumio, Françoise; Six, Emmanuelle; Cavazzana, Marina; Lagresle-Peyrou, Chantal; Soheili, Tayebeh; André, Isabelle

A DL-4- and TNFα-based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors. Journal Article

Cellular & molecular immunology, 18 , pp. 1662–1676, 2021, ISSN: 2042-0226.

Abstract | Links | Altmetric

Ingels, Joline; Smet, Saskia De; Heyns, Kelly; Lootens, Nele; Segaert, Jonas; Taghon, Tom; Leclercq, Georges; Vermaelen, Karim; Willems, Evelyne; Baudoux, Etienne; Kerre, Tessa; Baron, Frédéric; Vandekerckhove, Bart

Treatment of a patient with severe cytomegalovirus (CMV) infection after haploidentical stem cell transplantation with donor derived CMV specific T cells. Journal Article

Acta clinica Belgica, 76 , pp. 482–486, 2021, ISSN: 2295-3337.

Abstract | Links | Altmetric

Lorenzi, Lucia; Chiu, Hua-Sheng; Cobos, Francisco Avila; Gross, Stephen; Volders, Pieter-Jan; Cannoodt, Robrecht; Nuytens, Justine; Vanderheyden, Katrien; Anckaert, Jasper; Lefever, Steve; Tay, Aidan P; de Bony, Eric J; Trypsteen, Wim; Gysens, Fien; Vromman, Marieke; Goovaerts, Tine; Hansen, Thomas Birkballe; Kuersten, Scott; Nijs, Nele; Taghon, Tom; Vermaelen, Karim; Bracke, Ken R; Saeys, Yvan; Meyer, Tim De; Deshpande, Nandan P; Anande, Govardhan; Chen, Ting-Wen; Wilkins, Marc R; Unnikrishnan, Ashwin; Preter, Katleen De; Kjems, Jørgen; Koster, Jan; Schroth, Gary P; Vandesompele, Jo; Sumazin, Pavel; Mestdagh, Pieter

Publisher Correction: The RNA Atlas expands the catalog of human non-coding RNAs. Journal Article

Nature biotechnology, 39 , pp. 1467, 2021, ISSN: 1546-1696.

Links | Altmetric

Ferrua, Francesca; Bortolomai, Ileana; Fontana, Elena; Silvestre, Dario Di; Rigoni, Rosita; Marcovecchio, Genni Enza; Draghici, Elena; Brambilla, Francesca; Castiello, Maria Carmina; Delfanti, Gloria; Moshous, Despina; Picard, Capucine; Taghon, Tom; Bordon, Victoria; Schulz, Ansgar S; Schuetz, Catharina; Giliani, Silvia; Soresina, Annarosa; Gennery, Andrew R; Signa, Sara; Saldaña, Blachy Dávila J; Delmonte, Ottavia M; Notarangelo, Luigi D; Roifman, Chaim M; Poliani, Pietro Luigi; Uva, Paolo; Mauri, Pier Luigi; Villa, Anna; Bosticardo, Marita

Thymic Epithelial Cell Alterations and Defective Thymopoiesis Lead to Central and Peripheral Tolerance Perturbation in MHCII Deficiency. Journal Article

Frontiers in immunology, 12 , pp. 669943, 2021, ISSN: 1664-3224.

Abstract | Links | Altmetric

Decker, Matthias De; Lavaert, Marieke; Roels, Juliette; Tilleman, Laurentijn; Vandekerckhove, Bart; Leclercq, Georges; Nieuwerburgh, Filip Van; Vlierberghe, Pieter Van; Taghon, Tom

HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development. Journal Article

Haematologica, 106 , pp. 130–141, 2021, ISSN: 1592-8721.

Abstract | Links | Altmetric

Kiekens, Laura; Loocke, Wouter Van; Taveirne, Sylvie; Wahlen, Sigrid; Persyn, Eva; Ammel, Els Van; Vos, Zenzi De; Matthys, Patrick; Nieuwerburgh, Filip Van; Taghon, Tom; Vlierberghe, Pieter Van; Vandekerckhove, Bart; Leclercq, Georges

T-BET and EOMES Accelerate and Enhance Functional Differentiation of Human Natural Killer Cells. Journal Article

Frontiers in immunology, 12 , pp. 732511, 2021, ISSN: 1664-3224.

Abstract | Links | Altmetric

Bonte, Sarah; de Munter, Stijn; Billiet, Lore; Goetgeluk, Glenn; Ingels, Joline; Jansen, Hanne; Pille, Melissa; de Cock, Laurenz; Weening, Karin; Taghon, Tom; Leclercq, Georges; Vandekerckhove, Bart; Kerre, Tessa

In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality. Journal Article

Oncoimmunology, 10 , pp. 1954800, 2021, ISSN: 2162-402X.

Abstract | Links | Altmetric

Strubbe, Steven; Bruyne, Marieke De; Pannicke, Ulrich; Beyls, Elien; Vandekerckhove, Bart; Leclercq, Georges; Baere, Elfride De; Bordon, Victoria; Vral, Anne; Schwarz, Klaus; Haerynck, Filomeen; Taghon, Tom

A Novel Non-Coding Variant in DCLRE1C Results in Deregulated Splicing and Induces SCID Through the Generation of a Truncated ARTEMIS Protein That Fails to Support V(D)J Recombination and DNA Damage Repair. Journal Article

Frontiers in immunology, 12 , pp. 674226, 2021, ISSN: 1664-3224.

Abstract | Links | Altmetric

Tottone, Luca; Lancho, Olga; Loh, Jui-Wan; Singh, Amartya; Kimura, Shunsuke; Roels, Juliette; Kuchmiy, Anna; Strubbe, Steven; Lawlor, Matthew A; da Silva-Diz, Victoria; Luo, Shirley; Gachet, Stéphanie; García-Prieto, Carlos A; Hagelaar, Rico; Esteller, Manel; Meijerink, Jules P P; Soulier, Jean; Taghon, Tom; Vlierberghe, Pieter Van; Mullighan, Charles G; Khiabanian, Hossein; Rocha, Pedro P; Herranz, Daniel

A Tumor Suppressor Enhancer of PTEN in T-cell development and leukemia. Journal Article

Blood cancer discovery, 2 , pp. 92–109, 2021, ISSN: 2643-3249.

Abstract | Links | Altmetric

108 entries « 1 of 6 »