Publications

102 entries « 1 of 6 »

2022

Drobna-Śledzińska, Monika; Maćkowska-Maślak, Natalia; Jaksik, Roman; Kosmalska, Maria; Szarzyńska, Bronisława; Lejman, Monika; Sędek, Łukasz; Szczepański, Tomasz; Taghon, Tom; Vlierberghe, Pieter Van; Witt, Michał; Dawidowska, Małgorzata

Multiomics to investigate the mechanisms contributing to repression of PTPRC and SOCS2 in pediatric T-ALL: Focus on miR-363-3p and promoter methylation. Journal Article

Genes, chromosomes & cancer, 2022, ISSN: 1098-2264.

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Ingels, Joline; Cock, Laurenz De; Mayer, Rupert L; Devreker, Pam; Weening, Karin; Heyns, Kelly; Lootens, Nele; Smet, Saskia De; Brusseel, Marieke; Munter, Stijn De; Pille, Melissa; Billiet, Lore; Goetgeluk, Glenn; Bonte, Sarah; Jansen, Hanne; Lint, Sandra Van; Leclercq, Georges; Taghon, Tom; Menten, Björn; Vermaelen, Karim; Impens, Francis; Vandekerckhove, Bart

Small-scale manufacturing of neoantigen-encoding messenger RNA for early-phase clinical trials. Journal Article

Cytotherapy, 24 , pp. 213–222, 2022, ISSN: 1477-2566.

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Wahlen, Sigrid; Matthijssens, Filip; Loocke, Wouter Van; Taveirne, Sylvie; Kiekens, Laura; Persyn, Eva; Ammel, Els Van; Vos, Zenzi De; Munter, Stijn De; Matthys, Patrick; Nieuwerburgh, Filip Van; Taghon, Tom; Vandekerckhove, Bart; Vlierberghe, Pieter Van; Leclercq, Georges

The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency. Journal Article

eLife, 11 , 2022, ISSN: 2050-084X.

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2021

Strubbe, Steven; Taghon, Tom

Modeling of human T cell development in vitro as a read-out for hematopoietic stem cell multipotency. Journal Article

Biochemical Society transactions, 49 , pp. 2113–2122, 2021, ISSN: 1470-8752.

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Lorenzi, Lucia; Chiu, Hua-Sheng; Cobos, Francisco Avila; Gross, Stephen; Volders, Pieter-Jan; Cannoodt, Robrecht; Nuytens, Justine; Vanderheyden, Katrien; Anckaert, Jasper; Lefever, Steve; Tay, Aidan P; de Bony, Eric J; Trypsteen, Wim; Gysens, Fien; Vromman, Marieke; Goovaerts, Tine; Hansen, Thomas Birkballe; Kuersten, Scott; Nijs, Nele; Taghon, Tom; Vermaelen, Karim; Bracke, Ken R; Saeys, Yvan; Meyer, Tim De; Deshpande, Nandan P; Anande, Govardhan; Chen, Ting-Wen; Wilkins, Marc R; Unnikrishnan, Ashwin; Preter, Katleen De; Kjems, Jørgen; Koster, Jan; Schroth, Gary P; Vandesompele, Jo; Sumazin, Pavel; Mestdagh, Pieter

The RNA Atlas expands the catalog of human non-coding RNAs. Journal Article

Nature biotechnology, 39 , pp. 1453–1465, 2021, ISSN: 1546-1696.

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Moirangthem, Ranjita Devi; Ma, Kuiying; Lizot, Sabrina; Cordesse, Anne; Olivré, Juliette; de Chappedelaine, Corinne; Joshi, Akshay; Cieslak, Agata; Tchen, John; Cagnard, Nicolas; Asnafi, Vahid; Rausell, Antonio; Simons, Laura; Zuber, Julien; Taghon, Tom; Staal, Frank J T; Pflumio, Françoise; Six, Emmanuelle; Cavazzana, Marina; Lagresle-Peyrou, Chantal; Soheili, Tayebeh; André, Isabelle

A DL-4- and TNFα-based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors. Journal Article

Cellular & molecular immunology, 18 , pp. 1662–1676, 2021, ISSN: 2042-0226.

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Ingels, Joline; Smet, Saskia De; Heyns, Kelly; Lootens, Nele; Segaert, Jonas; Taghon, Tom; Leclercq, Georges; Vermaelen, Karim; Willems, Evelyne; Baudoux, Etienne; Kerre, Tessa; Baron, Frédéric; Vandekerckhove, Bart

Treatment of a patient with severe cytomegalovirus (CMV) infection after haploidentical stem cell transplantation with donor derived CMV specific T cells. Journal Article

Acta clinica Belgica, 76 , pp. 482–486, 2021, ISSN: 2295-3337.

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Lorenzi, Lucia; Chiu, Hua-Sheng; Cobos, Francisco Avila; Gross, Stephen; Volders, Pieter-Jan; Cannoodt, Robrecht; Nuytens, Justine; Vanderheyden, Katrien; Anckaert, Jasper; Lefever, Steve; Tay, Aidan P; de Bony, Eric J; Trypsteen, Wim; Gysens, Fien; Vromman, Marieke; Goovaerts, Tine; Hansen, Thomas Birkballe; Kuersten, Scott; Nijs, Nele; Taghon, Tom; Vermaelen, Karim; Bracke, Ken R; Saeys, Yvan; Meyer, Tim De; Deshpande, Nandan P; Anande, Govardhan; Chen, Ting-Wen; Wilkins, Marc R; Unnikrishnan, Ashwin; Preter, Katleen De; Kjems, Jørgen; Koster, Jan; Schroth, Gary P; Vandesompele, Jo; Sumazin, Pavel; Mestdagh, Pieter

Publisher Correction: The RNA Atlas expands the catalog of human non-coding RNAs. Journal Article

Nature biotechnology, 39 , pp. 1467, 2021, ISSN: 1546-1696.

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Ferrua, Francesca; Bortolomai, Ileana; Fontana, Elena; Silvestre, Dario Di; Rigoni, Rosita; Marcovecchio, Genni Enza; Draghici, Elena; Brambilla, Francesca; Castiello, Maria Carmina; Delfanti, Gloria; Moshous, Despina; Picard, Capucine; Taghon, Tom; Bordon, Victoria; Schulz, Ansgar S; Schuetz, Catharina; Giliani, Silvia; Soresina, Annarosa; Gennery, Andrew R; Signa, Sara; Saldaña, Blachy Dávila J; Delmonte, Ottavia M; Notarangelo, Luigi D; Roifman, Chaim M; Poliani, Pietro Luigi; Uva, Paolo; Mauri, Pier Luigi; Villa, Anna; Bosticardo, Marita

Thymic Epithelial Cell Alterations and Defective Thymopoiesis Lead to Central and Peripheral Tolerance Perturbation in MHCII Deficiency. Journal Article

Frontiers in immunology, 12 , pp. 669943, 2021, ISSN: 1664-3224.

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Decker, Matthias De; Lavaert, Marieke; Roels, Juliette; Tilleman, Laurentijn; Vandekerckhove, Bart; Leclercq, Georges; Nieuwerburgh, Filip Van; Vlierberghe, Pieter Van; Taghon, Tom

HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development. Journal Article

Haematologica, 106 , pp. 130–141, 2021, ISSN: 1592-8721.

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Kiekens, Laura; Loocke, Wouter Van; Taveirne, Sylvie; Wahlen, Sigrid; Persyn, Eva; Ammel, Els Van; Vos, Zenzi De; Matthys, Patrick; Nieuwerburgh, Filip Van; Taghon, Tom; Vlierberghe, Pieter Van; Vandekerckhove, Bart; Leclercq, Georges

T-BET and EOMES Accelerate and Enhance Functional Differentiation of Human Natural Killer Cells. Journal Article

Frontiers in immunology, 12 , pp. 732511, 2021, ISSN: 1664-3224.

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Bonte, Sarah; de Munter, Stijn; Billiet, Lore; Goetgeluk, Glenn; Ingels, Joline; Jansen, Hanne; Pille, Melissa; de Cock, Laurenz; Weening, Karin; Taghon, Tom; Leclercq, Georges; Vandekerckhove, Bart; Kerre, Tessa

In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality. Journal Article

Oncoimmunology, 10 , pp. 1954800, 2021, ISSN: 2162-402X.

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Strubbe, Steven; Bruyne, Marieke De; Pannicke, Ulrich; Beyls, Elien; Vandekerckhove, Bart; Leclercq, Georges; Baere, Elfride De; Bordon, Victoria; Vral, Anne; Schwarz, Klaus; Haerynck, Filomeen; Taghon, Tom

A Novel Non-Coding Variant in DCLRE1C Results in Deregulated Splicing and Induces SCID Through the Generation of a Truncated ARTEMIS Protein That Fails to Support V(D)J Recombination and DNA Damage Repair. Journal Article

Frontiers in immunology, 12 , pp. 674226, 2021, ISSN: 1664-3224.

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Tottone, Luca; Lancho, Olga; Loh, Jui-Wan; Singh, Amartya; Kimura, Shunsuke; Roels, Juliette; Kuchmiy, Anna; Strubbe, Steven; Lawlor, Matthew A; da Silva-Diz, Victoria; Luo, Shirley; Gachet, Stéphanie; García-Prieto, Carlos A; Hagelaar, Rico; Esteller, Manel; Meijerink, Jules P P; Soulier, Jean; Taghon, Tom; Vlierberghe, Pieter Van; Mullighan, Charles G; Khiabanian, Hossein; Rocha, Pedro P; Herranz, Daniel

A Tumor Suppressor Enhancer of PTEN in T-cell development and leukemia. Journal Article

Blood cancer discovery, 2 , pp. 92–109, 2021, ISSN: 2643-3249.

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2020

Buratin, Alessia; Paganin, Maddalena; Gaffo, Enrico; Molin, Anna Dal; Roels, Juliette; Germano, Giuseppe; Siddi, Maria Teresa; Serafin, Valentina; Decker, Matthias De; Gachet, Stéphanie; Durinck, Kaat; Speleman, Frank; Taghon, Tom; Kronnie, Geertruij Te; Vlierberghe, Pieter Van; Bortoluzzi, Stefania

Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes. Journal Article

Blood advances, 4 , pp. 5902–5914, 2020, ISSN: 2473-9537.

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Billiet, Lore; Goetgeluk, Glenn; Bonte, Sarah; Munter, Stijn De; Cock, Laurenz De; Pille, Melissa; Ingels, Joline; Jansen, Hanne; Weening, Karin; Nieuwerburgh, Filip Van; Kerre, Tessa; Taghon, Tom; Leclercq, Georges; Vandekerckhove, Bart

Human Thymic CD10+ PD-1+ Intraepithelial Lymphocyte Precursors Acquire Interleukin-15 Responsiveness at the CD1a– CD95+ CD28– CCR7– Developmental Stage Journal Article

International journal of molecular sciences, 21 , 2020, ISSN: 1422-0067.

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Roels, Juliette; Thénoz, Morgan; Szarzyńska, Bronisława; Landfors, Mattias; Coninck, Stien De; Demoen, Lisa; Provez, Lien; Kuchmiy, Anna; Strubbe, Steven; Reunes, Lindy; Pieters, Tim; Matthijssens, Filip; Loocke, Wouter Van; Erarslan-Uysal, Büşra; Richter-Pechańska, Paulina; Declerck, Ken; Lammens, Tim; Moerloose, Barbara De; Deforce, Dieter; Nieuwerburgh, Filip Van; Cheung, Laurence C; Kotecha, Rishi S; Mansour, Marc R; Ghesquière, Bart; Camp, Guy Van; Berghe, Wim Vanden; Kowalczyk, Jerzy R; Szczepański, Tomasz; Davé, Utpal P; Kulozik, Andreas E; Goossens, Steven; Curtis, David J; Taghon, Tom; Dawidowska, Małgorzata; Degerman, Sofie; Vlierberghe, Pieter Van

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia. Journal Article

Blood cancer discovery, 1 , pp. 274–289, 2020, ISSN: 2643-3249.

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Taveirne, Sylvie; Wahlen, Sigrid; Loocke, Wouter Van; Kiekens, Laura; Persyn, Eva; Ammel, Els Van; Mulder, Katrien De; Roels, Juliette; Tilleman, Laurentijn; Aumercier, Marc; Matthys, Patrick; Nieuwerburgh, Filip Van; Kerre, Tessa C C; Taghon, Tom; Vlierberghe, Pieter Van; Vandekerckhove, Bart; Leclercq, Georges

The transcription factor ETS1 is an important regulator of human NK cell development and terminal differentiation. Journal Article

Blood, 136 , pp. 288–298, 2020, ISSN: 1528-0020.

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Smedt, Renate De; Morscio, Julie; Reunes, Lindy; Roels, Juliette; Bardelli, Valentina; Lintermans, Beatrice; Loocke, Wouter Van; Almeida, Afonso; Cheung, Laurence C; Kotecha, Rishi S; Mansour, Marc R; Uyttebroeck, Anne; Vandenberghe, Peter; Starza, Roberta La; Mecucci, Cristina; Lammens, Tim; Roy, Nadine Van; Moerloose, Barbara De; Barata, João T; Taghon, Tom; Goossens, Steven; Vlierberghe, Pieter Van

Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma. Journal Article

Blood, 135 , pp. 1685–1695, 2020, ISSN: 1528-0020.

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Dolens, Anne-Catherine; Durinck, Kaat; Lavaert, Marieke; der Meulen, Joni Van; Velghe, Imke; Medts, Jelle De; Weening, Karin; Roels, Juliette; Mulder, Katrien De; Volders, Pieter-Jan; Preter, Katleen De; Kerre, Tessa; Vandekerckhove, Bart; Leclercq, Georges; Vandesompele, Jo; Mestdagh, Pieter; Vlierberghe, Pieter Van; Speleman, Frank; Taghon, Tom

Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development. Journal Article

EMBO reports, 21 , pp. e49006, 2020, ISSN: 1469-3178.

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102 entries « 1 of 6 »