In my PhD project, I aim to investigate how oxygen availability in the thymus influences T cell development, with a particular focus on the molecular mechanisms and signaling pathways activated under hypoxic conditions.

With a background in Biomedical Sciences and a specialization in immunology, I am currently pursuing a PhD focused on T cell differentiation. This process takes place in the thymus, where hematopoietic progenitors from the bone marrow undergo a tightly regulated maturation process to form a diverse and self-tolerant T cell repertoire. My PhD project aims to investigate how oxygen availability in the thymus influences T cell development, with a particular focus on the molecular mechanisms and signaling pathways activated under hypoxic conditions. To address this, I am using advanced techniques such as proteomics, transcriptomics and immunofluorescence imaging are used. Insights from this project are expected to inform protocols for in vitro T cell production, with direct implications for improving T cell-based immunotherapies.