Publications

109 entries « 2 of 6 »

2021

Tottone, Luca; Lancho, Olga; Loh, Jui-Wan; Singh, Amartya; Kimura, Shunsuke; Roels, Juliette; Kuchmiy, Anna; Strubbe, Steven; Lawlor, Matthew A; da Silva-Diz, Victoria; Luo, Shirley; Gachet, Stéphanie; García-Prieto, Carlos A; Hagelaar, Rico; Esteller, Manel; Meijerink, Jules P P; Soulier, Jean; Taghon, Tom; Vlierberghe, Pieter Van; Mullighan, Charles G; Khiabanian, Hossein; Rocha, Pedro P; Herranz, Daniel

A Tumor Suppressor Enhancer of PTEN in T-cell development and leukemia. Journal Article

Blood cancer discovery, 2 , pp. 92–109, 2021, ISSN: 2643-3249.

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2020

Buratin, Alessia; Paganin, Maddalena; Gaffo, Enrico; Molin, Anna Dal; Roels, Juliette; Germano, Giuseppe; Siddi, Maria Teresa; Serafin, Valentina; Decker, Matthias De; Gachet, Stéphanie; Durinck, Kaat; Speleman, Frank; Taghon, Tom; Kronnie, Geertruij Te; Vlierberghe, Pieter Van; Bortoluzzi, Stefania

Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes. Journal Article

Blood advances, 4 , pp. 5902–5914, 2020, ISSN: 2473-9537.

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Billiet, Lore; Goetgeluk, Glenn; Bonte, Sarah; Munter, Stijn De; Cock, Laurenz De; Pille, Melissa; Ingels, Joline; Jansen, Hanne; Weening, Karin; Nieuwerburgh, Filip Van; Kerre, Tessa; Taghon, Tom; Leclercq, Georges; Vandekerckhove, Bart

Human Thymic CD10+ PD-1+ Intraepithelial Lymphocyte Precursors Acquire Interleukin-15 Responsiveness at the CD1a– CD95+ CD28– CCR7– Developmental Stage Journal Article

International journal of molecular sciences, 21 , 2020, ISSN: 1422-0067.

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Roels, Juliette; Thénoz, Morgan; Szarzyńska, Bronisława; Landfors, Mattias; Coninck, Stien De; Demoen, Lisa; Provez, Lien; Kuchmiy, Anna; Strubbe, Steven; Reunes, Lindy; Pieters, Tim; Matthijssens, Filip; Loocke, Wouter Van; Erarslan-Uysal, Büşra; Richter-Pechańska, Paulina; Declerck, Ken; Lammens, Tim; Moerloose, Barbara De; Deforce, Dieter; Nieuwerburgh, Filip Van; Cheung, Laurence C; Kotecha, Rishi S; Mansour, Marc R; Ghesquière, Bart; Camp, Guy Van; Berghe, Wim Vanden; Kowalczyk, Jerzy R; Szczepański, Tomasz; Davé, Utpal P; Kulozik, Andreas E; Goossens, Steven; Curtis, David J; Taghon, Tom; Dawidowska, Małgorzata; Degerman, Sofie; Vlierberghe, Pieter Van

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia. Journal Article

Blood cancer discovery, 1 , pp. 274–289, 2020, ISSN: 2643-3249.

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Taveirne, Sylvie; Wahlen, Sigrid; Loocke, Wouter Van; Kiekens, Laura; Persyn, Eva; Ammel, Els Van; Mulder, Katrien De; Roels, Juliette; Tilleman, Laurentijn; Aumercier, Marc; Matthys, Patrick; Nieuwerburgh, Filip Van; Kerre, Tessa C C; Taghon, Tom; Vlierberghe, Pieter Van; Vandekerckhove, Bart; Leclercq, Georges

The transcription factor ETS1 is an important regulator of human NK cell development and terminal differentiation. Journal Article

Blood, 136 , pp. 288–298, 2020, ISSN: 1528-0020.

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Smedt, Renate De; Morscio, Julie; Reunes, Lindy; Roels, Juliette; Bardelli, Valentina; Lintermans, Beatrice; Loocke, Wouter Van; Almeida, Afonso; Cheung, Laurence C; Kotecha, Rishi S; Mansour, Marc R; Uyttebroeck, Anne; Vandenberghe, Peter; Starza, Roberta La; Mecucci, Cristina; Lammens, Tim; Roy, Nadine Van; Moerloose, Barbara De; Barata, João T; Taghon, Tom; Goossens, Steven; Vlierberghe, Pieter Van

Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma. Journal Article

Blood, 135 , pp. 1685–1695, 2020, ISSN: 1528-0020.

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Dolens, Anne-Catherine; Durinck, Kaat; Lavaert, Marieke; der Meulen, Joni Van; Velghe, Imke; Medts, Jelle De; Weening, Karin; Roels, Juliette; Mulder, Katrien De; Volders, Pieter-Jan; Preter, Katleen De; Kerre, Tessa; Vandekerckhove, Bart; Leclercq, Georges; Vandesompele, Jo; Mestdagh, Pieter; Vlierberghe, Pieter Van; Speleman, Frank; Taghon, Tom

Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development. Journal Article

EMBO reports, 21 , pp. e49006, 2020, ISSN: 1469-3178.

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Park, Jong-Eun; Botting, Rachel A; Conde, Cecilia Domínguez; Popescu, Dorin-Mirel; Lavaert, Marieke; Kunz, Daniel J; Goh, Issac; Stephenson, Emily; Ragazzini, Roberta; Tuck, Elizabeth; Wilbrey-Clark, Anna; Roberts, Kenny; Kedlian, Veronika R; Ferdinand, John R; He, Xiaoling; Webb, Simone; Maunder, Daniel; Vandamme, Niels; Mahbubani, Krishnaa T; Polanski, Krzysztof; Mamanova, Lira; Bolt, Liam; Crossland, David; de Rita, Fabrizio; Fuller, Andrew; Filby, Andrew; Reynolds, Gary; Dixon, David; Saeb-Parsy, Kourosh; Lisgo, Steven; Henderson, Deborah; Vento-Tormo, Roser; Bayraktar, Omer A; Barker, Roger A; Meyer, Kerstin B; Saeys, Yvan; Bonfanti, Paola; Behjati, Sam; Clatworthy, Menna R; Taghon, Tom; Haniffa, Muzlifah; Teichmann, Sarah A

A cell atlas of human thymic development defines T cell repertoire formation. Journal Article

Science (New York, N.Y.), 367 , 2020, ISSN: 1095-9203.

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Loontiens, Siebe; Dolens, Anne-Catherine; Strubbe, Steven; de Walle, Inge Van; Moore, Finola E; Depestel, Lisa; Vanhauwaert, Suzanne; Matthijssens, Filip; Langenau, David M; Speleman, Frank; Vlierberghe, Pieter Van; Durinck, Kaat; Taghon, Tom

PHF6 Expression Levels Impact Human Hematopoietic Stem Cell Differentiation. Journal Article

Frontiers in cell and developmental biology, 8 , pp. 599472, 2020, ISSN: 2296-634X.

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Zhou, Yalu; Han, Cuijuan; Wang, Eric; Lorch, Adam H; Serafin, Valentina; Cho, Byoung-Kyu; Diaz, Blanca Gutierrez T; Calvo, Julien; Fang, Celestia; Khodadadi-Jamayran, Alireza; Tabaglio, Tommaso; Marier, Christian; Kuchmiy, Anna; Sun, Limin; Yacu, George; Filip, Szymon K; Jin, Qi; Takahashi, Yoh-Hei; Amici, David R; Rendleman, Emily J; Rawat, Radhika; Bresolin, Silvia; Paganin, Maddalena; Zhang, Cheng; Li, Hu; Kandela, Irawati; Politanska, Yuliya; Abdala-Valencia, Hiam; Mendillo, Marc L; Zhu, Ping; Palhais, Bruno; Vlierberghe, Pieter Van; Taghon, Tom; Aifantis, Iannis; Goo, Young Ah; Guccione, Ernesto; Heguy, Adriana; Tsirigos, Aristotelis; Wee, Keng Boon; Mishra, Rama K; Pflumio, Francoise; Accordi, Benedetta; Basso, Giuseppe; Ntziachristos, Panagiotis

Posttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia. Journal Article

Cancer discovery, 10 , pp. 1388–1409, 2020, ISSN: 2159-8290.

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Lavaert, Marieke; Valcke, Brecht; Vandekerckhove, Bart; Leclercq, Georges; Liang, Kai Ling; Taghon, Tom

Conventional and Computational Flow Cytometry Analyses Reveal Sustained Human Intrathymic T Cell Development From Birth Until Puberty. Journal Article

Frontiers in immunology, 11 , pp. 1659, 2020, ISSN: 1664-3224.

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Lavaert, Marieke; Liang, Kai Ling; Vandamme, Niels; Park, Jong-Eun; Roels, Juliette; Kowalczyk, Monica S; Li, Bo; Ashenberg, Orr; Tabaka, Marcin; Dionne, Danielle; Tickle, Timothy L; Slyper, Michal; Rozenblatt-Rosen, Orit; Vandekerckhove, Bart; Leclercq, Georges; Regev, Aviv; Vlierberghe, Pieter Van; Guilliams, Martin; Teichmann, Sarah A; Saeys, Yvan; Taghon, Tom

Integrated scRNA-Seq Identifies Human Postnatal Thymus Seeding Progenitors and Regulatory Dynamics of Differentiating Immature Thymocytes. Journal Article

Immunity, 52 , pp. 1088–1104.e6, 2020, ISSN: 1097-4180.

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Roels, Juliette; Kuchmiy, Anna; Decker, Matthias De; Strubbe, Steven; Lavaert, Marieke; Liang, Kai Ling; Leclercq, Georges; Vandekerckhove, Bart; Nieuwerburgh, Filip Van; Vlierberghe, Pieter Van; Taghon, Tom

Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development. Journal Article

Nature immunology, 21 , pp. 1280–1292, 2020, ISSN: 1529-2916.

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Drobna, Monika; Szarzyńska, Bronisława; Jaksik, Roman; Sędek, Łukasz; Kuchmiy, Anna; Taghon, Tom; Vlierberghe, Pieter Van; Szczepański, Tomasz; Witt, Michał; Dawidowska, Małgorzata

hsa-miR-20b-5p and hsa-miR-363-3p Affect Expression of PTEN and BIM Tumor Suppressor Genes and Modulate Survival of T-ALL Cells In Vitro Journal Article

Cells, 9 , 2020, ISSN: 2073-4409.

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Bonte, Sarah; Munter, Stijn De; Goetgeluk, Glenn; Ingels, Joline; Pille, Melissa; Billiet, Lore; Taghon, Tom; Leclercq, Georges; Vandekerckhove, Bart; Kerre, Tessa

T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources Journal Article

Oncoimmunology, 9 , pp. 1727078, 2020, ISSN: 2162-4011.

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Munter, Stijn De; Parys, Alexander Van; Bral, Layla; Ingels, Joline; Goetgeluk, Glenn; Bonte, Sarah; Pille, Melissa; Billiet, Lore; Weening, Karin; Verhee, Annick; der Heyden, Jose Van; Taghon, Tom; Leclercq, Georges; Kerre, Tessa; Tavernier, Jan; Vandekerckhove, Bart

Rapid and Effective Generation of Nanobody Based CARs using PCR and Gibson Assembly. Journal Article

International journal of molecular sciences, 21 , 2020, ISSN: 1422-0067.

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2019

Coninck, Stien De; Berx, Geert; Taghon, Tom; Vlierberghe, Pieter Van; Goossens, Steven

ZEB2 in T-cells and T-ALL. Journal Article

Advances in biological regulation, 74 , pp. 100639, 2019, ISSN: 2212-4934.

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Bonnardel, Johnny; T'Jonck, Wouter; Gaublomme, Djoere; Browaeys, Robin; Scott, Charlotte L; Martens, Liesbet; Vanneste, Bavo; Prijck, Sofie De; Nedospasov, Sergei A; Kremer, Anna; Hamme, Evelien Van; Borghgraef, Peter; Toussaint, Wendy; Bleser, Pieter De; Mannaerts, Inge; Beschin, Alain; van Grunsven, Leo A; Lambrecht, Bart N; Taghon, Tom; Lippens, Saskia; Elewaut, Dirk; Saeys, Yvan; Guilliams, Martin

Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche. Journal Article

Immunity, 51 , pp. 638–654.e9, 2019, ISSN: 1097-4180.

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de Bock, Charles E; Down, Michelle; Baidya, Kinsha; Sweron, Bram; Boyd, Andrew W; Fiers, Mark; Burns, Gordon F; Molloy, Timothy J; Lock, Richard B; Soulier, Jean; Taghon, Tom; Vlierberghe, Pieter Van; Cools, Jan; Holst, Jeff; Thorne, Rick F

T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development. Journal Article

Haematologica, 104 , pp. e204–e207, 2019, ISSN: 1592-8721.

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Habets, Roger A; de Bock, Charles E; Serneels, Lutgarde; Lodewijckx, Inge; Verbeke, Delphine; Nittner, David; Narlawar, Rajeshwar; Demeyer, Sofie; Dooley, James; Liston, Adrian; Taghon, Tom; Cools, Jan; de Strooper, Bart

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition. Journal Article

Science translational medicine, 11 , 2019, ISSN: 1946-6242.

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109 entries « 2 of 6 »