T cells are essential white blood cells from the adaptive immune system – they protect us from pathogens and also kill tumour cells. In contrast to all other blood cells that develop in the bone marrow where also the hematopoietic stem cells (HSC) reside, T cell development takes place within the thymus. A decreased number of T cells, a … Read more
FWO Postdoctoral Fellow My research focusses on the development of αβ and αδ T cells in the human thymus. To study the epigenetic drivers underlying their differentiation at high resolution, I make use of various single cell approaches such as scRNA-seq, scATAC-seq and CITE-seq. B.Sc. Molecular Biomedicine (2014, University of Bonn, Germany) M.Sc. Molecular Medicine … Read more
Els studied the role of Notch3 at discrete developmental stages of human T cell development during her PhD in our lab.
During her postdoc in our lab from 2011 until 2016, Katrien optimised the gene-editing of human embryonic stem cells to study human hematopoeiesis.
Inge was a member of the lab from 2002 until 2016, first as technician, then as PhD student and eventually as post doctoral researcher. During these years, Inge focused on the elucidation of Notch activation during human T cell development.
My research is focused on the transcription factor GATA3, a key regulator of commitment of hematopoietic progenitor cells to the T cell lineage. Interestingly, recurrent mutations have been reported in GATA3 in patients with early T-cell precursor acute lymphoblastic leukemia (ETP-ALL), which is a subtype of T-ALL. So far, it is still unclear whether GATA3 … Read more